PARSIPPANY, N.J., - DSM announced today that its proprietary XD(R) Technology boosts bioreactor productivity and titers of mammalian cell culture processes by 5-10 fold for the production of proteins and antibodies.
Recent studies completed at the R&D labs of DSM Biologics in Groningen, The Netherlands demonstrated that the yields from CHO-based cell cultures can be increased 5-10 fold over their previous fed-batch processes using only off the shelf, commercially available media. The XD(R) Technology has been tested for antibody and recombinant protein production across multiple cell lines, and the increase was realized in all cases.
By dramatically increasing the cell density of a culture, the XD(R) Technology offers the opportunity to substantially increase titers in a very short time without changing the cell line or process media. This can economically save a project already advanced in clinical development and prevent loss of time.
Jaap Schilder, Site Director Groningen, comments, "This opens the door to a completely novel way of supplying drug substance for clinical trials and for market needs. The XD(R) process increases the overall output of a facility dramatically and the process duration and handling is similar to any fed-batch process. Development spending, time to market and cost of goods will all be significantly reduced by applying this technology. Now, up to several kilograms of drug substance can be manufactured in a single batch from small disposable bioreactors."
Karen King, President at DSM Biologics, adds, "Our XD(R) Technology offers a substantial increase in titers and reactor output and has the potential to increase product quality as the producer cells are maintained at extremely high viability throughout the entire process. Clients can use the XD(R) Technology within their existing infrastructure or it can be the basis of an optimized new plant design offering costs-of-goods advantages and reductions in capital expenditure."
DSM is currently working with multiple customers at the Groningen site for XD(R) process development. They are booking development slots now for the remainder of 2009 and 2010.
DSM Pharmaceutical Products
DSM Pharmaceutical Products is a global provider of high quality custom contract manufacturing and development services to the pharmaceutical and biopharmaceutical industries. DSM contract manufacturing services include: chemical development, registered intermediates, registered starting materials, active pharmaceutical ingredients (API's), fermentation, mammalian cell production of monoclonal antibodies and proteins, formulation development, clinical trial manufacturing and finished dose form manufacturing of solids, semi-solids, and scheduled drugs, aseptic liquid and lyophilized products
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